The Global Heart Hub is made up of different Patient Councils. Each council is an alliance of different patient organisations, who have a common interest in specific cardiovascular conditions or a number of related conditions. Currently, Patient Councils include a Heart Failure Patient Council, a Heart Valve Disease Patient Council and a Cardiomyopathy Patient Council.

In advance of establishing a Patient Council, the Global Heart Hub convenes a Working Group. Currently, there is one Working Group on Cardio Diabetes.